Our paper on how nucleosomes influence mutation rate leading to a 10bp periodic pattern is out in Cell

By |2023-11-08T09:54:27+00:00November 7th, 2018|Categories: BG News, Uncategorized|Tags: , , , , , |

We are very excited to share that our work describing the somatic and germline 10bp periodicity in the mutation rate within nucleosome-bound DNA was published in the [...]

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A Cancer Genome Interpreter to identify driver and actionable alterations in tumors

By |2023-11-08T09:54:28+00:00October 5th, 2016|Categories: BG News|Tags: , , |

The use of genomic information is becoming a key piece of the oncology toolkit to make informed decisions aimed to improve the management of the disease and increase the cost-effectiveness of available therapies.

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Our paper demonstrating that proteins bound to DNA impair Nucleotide Excision Repair published in Nature

By |2023-11-08T09:54:28+00:00April 14th, 2016|Categories: BG News|Tags: , , |

I am very happy to announce that our manuscript describing the increased mutation rate in Transcription Factor Binding Sites (TFBS) in melanomas and lung tumors has been published in today's issue of Nature. In the manuscript we demonstrate that this accumulation is due to the impairment of Nucleotide Excision Repair (NER) activity by proteins bound to DNA.

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