The use of genomic information is becoming a key piece of the oncology toolkit to make informed decisions aimed to improve the management of the disease and increase the cost-effectiveness of available therapies.
Cancers are typically classified depending on their tissue of origin. However, novel large-scale genomic studies are providing more detailed molecular characterizations of tumors, and thus bring about [...]
The Cancer Genome Atlas (TCGA) is an initiative supported by the National Cancer Institute and the National Human Genome Research Institute. Its immediate aim is to obtain [...]
We have recently developed a novel method, named OncodriveCLUST, aimed to analyse the mutations observed in sets of tumor samples and identify genes involved in the disease. [...]
Oncodrive-CIS: a method to reveal likely driver genes based on the impact of their copy number changes on expression.
One of the current challenges of oncogenomics is to elucidate which of the aberrations observed in the cancer genome is involved in the disease and which of [...]