Condel for prioritization of variants involved in hereditary diseases and transFIC for cancer
We have worked during the last years on assessing the functional impact of non-synonymous variants (nsSNVs). As a result, we have published two new approaches Condel and transFIC. [...]
December 14, 2012
How to evaluate the performance of computational methods to identify driver mutations?
We have recently published transFIC, a computational method to assess the functional impact of somatic cancer mutations (see this post). To evaluate the performance of transFIC we needed [...]
November 30, 2012
How to prioritize cancer somatic mutations?
Projects that sequence the genomes of a cohort of tumor samples are faced with the challenge of deciding which somatic mutations are relevant to tumor development (drivers). The [...]
November 5, 2012
Systematic identification of cancer drivers across tumor types in IntOGen
This post is to share with you the poster describing “Systematic identification of cancer drivers across tumor types in IntOGen” that was presented last week at the Cambridge Research [...]
November 5, 2012
TransFIC and OncodriveFM: Tools for the analysis of cancer sequencing data
This post is to share with you the poster describing “TransFIC and OncodriveFM: Tools for the analysis of cancer sequencing data” that was presented last week at the Cambridge [...]
October 25, 2012
How does full repression of cell cycle gene occur during differentiation ?
The ability of the retinoblastoma protein (pRB) to restrict the cell cycle is well known. Since KDM5A/RBP2/JARID1A is associated with pRB/E2F, one may wonder about its recruitment and [...]
October 18, 2012
Gitools 1.7.0: The new features
We have been preparing a new version of Gitools with many improvements, amongst which there is a new IGV search, the use of categorical scales and new data aggregation [...]
October 16, 2012
IntOGen V.04: with somatic mutations from cancer genome sequencing projects
We are proud to share with you the Beta version of IntOGen V.04 at http://beta.intogen.org. This new version includes many changes both in content and in layout. In [...]
October 9, 2012
Modifications in condel server
Several weeks ago we realized we were having problems retrieving the functional impact scores from the MutationAssessor webservice into our condel web server. We immediately corrected the problem [...]
September 18, 2012
Awards from UPF to members of our lab
Members of our lab received yesterday two awards from the Social Council of the University Pompeu Fabra. […]
