We have recently published transFIC, a computational method to assess the functional impact of somatic cancer mutations (see this post). To evaluate the performance of transFIC we needed [...]

Projects that sequence the genomes of a cohort of tumor samples are faced with the challenge of deciding which somatic mutations are relevant to tumor development (drivers). The [...]

This post is to share with you the poster describing “Systematic identification of cancer drivers across tumor types in IntOGen” that was presented last week at the Cambridge Research [...]

This post is to share with you the poster describing “TransFIC and OncodriveFM: Tools for the analysis of cancer sequencing data” that was presented last week at the Cambridge [...]

The ability of the retinoblastoma protein (pRB) to restrict the cell cycle is well known. Since KDM5A/RBP2/JARID1A is associated with pRB/E2F, one may wonder about its recruitment and [...]

We have been preparing a new version of Gitools with many improvements, amongst which there is a new IGV search, the use of categorical scales and new data aggregation [...]

  We are proud to share with you the Beta version of IntOGen V.04 at http://beta.intogen.org. This new version includes many changes both in content and in layout. In [...]

Several weeks ago we realized we were having problems retrieving the functional impact scores from the MutationAssessor webservice into our condel web server. We immediately corrected the problem [...]

Members of our lab received yesterday two awards from the Social Council of the University Pompeu Fabra. […]

I have recently seen several presentations by groups that systematically explore alterations in cancer genomes that deliver the same message. One of the main challenges faced [...]