Comprehensive identification of mutational cancer driver genes across 12 tumor types
The Cancer Genome Atlas (TCGA) is an initiative supported by the National Cancer Institute and the National Human Genome Research Institute. Its immediate aim is to obtain a [...]
September 27, 2013
The Cancer Genome Atlas Pan-Cancer Project
Yesterday the paper describing TCGA Pan-Cancer Project was published in Nature Genetics. We’ve had the opportunity to participate in this exciting project and here I would like to [...]
September 25, 2013
Chromatin maintenance and cancer
It is now well established that cancer is a collection of mostly genetic diseases. They progress through the accumulation of alterations, such as point mutations in genes that [...]
September 16, 2013
IntOGen-mutations: the analysis of cancer genomes published in Nature Methods
Yesterday night, our IntOGen-mutations paper went online in Nature Methods. A couple of years of hard work of our team lies now condensed into a couple of pages. [...]
August 21, 2013
OncodriveCLUST: a method to reveal cancer drivers based on mutation clustering
We have recently developed a novel method, named OncodriveCLUST, aimed to analyse the mutations observed in sets of tumor samples and identify genes involved in the disease. It [...]
August 2, 2013
How to identify functional genetic variants in cancer genomes?
The possibility to rapidly and inexpensively sequence tumor genomes is opening important new avenues for cancer research. One of the main objectives when sequencing tumor genomes is to [...]
July 25, 2013
Interactive heat-maps to explore biological data
Heat-maps are graphical representations of data where values in a matrix are represented following a color scale. This way of representing data has proven to be a very [...]
July 5, 2013
Barcelona Summer School of Genomics and Bioinformatics 2013
This year the Barcelona Summer School of Genomics and Bioinformatics is offering two courses, one on "Next Generation Sequencing for Medical Genomics", coordinated by Ferran Casals from the [...]
June 27, 2013
List of tools to visualize multidimensional cancer genomics data
A while ago we published a review about multidimensional cancer genomics data visualization in Genome Medicine. There, we focused on effective and common visualization techniques for exploring oncogenomics data [...]
May 10, 2013
The Biology of Genomes meeting at CSHL: my poster about IntOGen
This is a very short post to share the poster that I am presenting this week at the Biology of Genomes meeting in CSHL. […]