Sex and smoking bias in the selection of somatic mutations in human bladder
Our latest study about somatic mutations in the human bladder is now published in Nature. Using ultradeep DNA duplex sequencing we can measure the clonal landscape of normal human bladder in an informative and scalable manner. In a cohort of 45 donors, we find that bladder cancer risk factors, such as sex and smoking, shape the clonal landscape of the normal bladder tissue in specific ways that could help explain the differences in risk between males and females and in smokers.
