Introduction¶
FannsDB stands for Functional ANnotations for Non Synonymous SNVs Database. It is basically the unified data back-end used by both Condel and TransFIC. Please, follow these links for further information:
Data sources¶
FannsDB integrates data from several sources:
Ensembl version 64 (september 2011):
All the transcript and protein identifiers correspond to this version of Ensembl as well as all the external references: Hugo symbol, Swissprot ID and Accession, RefSeq.
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dbNSFP is a database developed for functional prediction and annotation of all potential non-synonymous single-nucleotide variants (nsSNVs) in the human genome. We use it to get the following predictors (see also the version included in dbNSFP):
- MutationAssessor: release 2 http://mutationassessor.org/
- FATHMM for disease: v2.3 http://fathmm.biocompute.org.uk
Note that we calculate FATHMM for cancer directly from the data and tools provided by the authors.